I run mostly using all mouse[both mouse buttons], bind z,x as strafe[Thumb]. Tab to switch targets with my pinky. Use number keys[other fingers] and bind my other skills in Quickslots using alt/ctrl/shift [thumb] + # for skills and try and group them based on what they do moving less used skills farther down the keyboard. I enabled the center bottom slot and bound all those to alt + # and put my close range stuff down there. # keys by themselves are ranged. CTRL + # for toggling stuff like stealth or healing.
I don't know if its ideal or not but it works for me. If you search mouseturning on youtube there are some videos out there but I can't keybind to anything but numbers or my brain vomits and they bind to the letters around w,a,s,d or e,s,d,f for skills and bind the keys to turn as strafe instead and use the mouse to help turn. I tried to find the one I watched last week that did a good job of explaining, I just can't operate that way. Will keep looking.